Database : HANSEN Search on : HEPATITE TOXICA [Subject descriptor] References found : 7 [refine] Displaying: 1 .. 7   in format [Detailed]

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Id: 15627 Author: Kaluarachchi, S. I; Fernandopulle, B. M. R; Gunawardane, B. P Title: Hepatic and haematological adverse reactions associated with the use of multidrug therapy in leprosy - a five year retrospective study ..- Source: s.l; s.n; 2001. 9 p. tab. Abstract: This study analyses retrospectively some of the risks associated with the use of WHO-multidrug therapy (MDT) in Sri Lanka. Case records of 3,333 new cases of leprosy attending the Central Leprosy Clinic in Colombo during 1991-1995, were analysed for adverse drug reactions involving the liver and blood. There were 81 reports of suspected hepatic or haematological adverse reactions associated with the use of MDT, of which 39 were classified as haemolytic anaemia, 25 as toxic hepatitis, 2 as methaemoglobinaemia and 15 as anaemia. Dapsone, was incriminated in the majority of adverse reactions (72 per cent). Adverse drug reactions were more common in female than male subjects (55 per cent vs 45 per cent; P < 0.5), but there was no significant differences between the age groups. Majority of adverse reactions was seen within the first three months of initiation of MDT. This study in no way undermines the benefits of MDT but highlights the risks and suggests measures to minimize these risks. (AU). Descriptors: ANEMIA/ind quim ANEMIA/epidemiol CLOFAZIMINA/ef adv DAPSONA/ef adv QUIMIOTERAPIA COMBINADA HEPATITE TOXICA/epidemiol HANSENOSTATICOS/ef adv HANSENOSTATICOS/uso terap HANSENIASE/quimioter ESTUDOS RETROSPECTIVOS RIFAMPINA/ef adv RIFAMPINA/uso terap METEMOGLOBINEMIA/ind quim METEMOGLOBINEMIA/epidemiol Limits: HUMANO MASCULINO FEMININO CRIANÇA ADULTO MEIA-IDADE ADOLESCENTE Electronic Medium: http://www.ilsl.br Location: BR191.1; 09163/s

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Id: 13655 Author: Kaluarachchi, S. I; Fernandopulle, B. M. R; Gunawardane, B. P Title: Hepatic and haematological adverse reactions associated with the use of multidrug therapy in leprosy - a five year retrospective study ..- Source: s.l; s.n; 2001. 9 p. tab. Abstract: This study analyses retrospectively some of the risks associated with the use of WHO-multidrug therapy (MDT) in Sri Lanka. Case records of 3,333 new cases of leprosy attending the Central Leprosy Clinic in Colombo during 1991-1995, were analysed for adverse drug reactions involving the liver and blood. There were 81 reports of suspected hepatic or haematological adverse reactions associated with the use of MDT, of which 39 were classified as haemolytic anaemia, 25 as toxic hepatitis, 2 as methaemoglobinaemia and 15 as anaemia. Dapsone, was incriminated in the majority of adverse reactions (72 per cent). Adverse drug reactions were more common in female than male subjects (55 per cent vs 45 per cent; P < 0.5), but there was no significant differences between the age groups. Majority of adverse reactions was seen within the first three months of initiation of MDT. This study in no way undermines the benefits of MDT but highlights the risks and suggests measures to minimize these risks. (AU). Descriptors: ANEMIA/ind quim ANEMIA/epidemiol CLOFAZIMINA/ef adv DAPSONA/ef adv QUIMIOTERAPIA COMBINADA HEPATITE TOXICA/epidemiol HANSENOSTATICOS/ef adv HANSENOSTATICOS/uso terap HANSENIASE/quimioter METEMOGLOBINEMIA/ind quim METEMOGLOBINEMIA/epidemiol ESTUDOS RETROSPECTIVOS RIFAMPINA/ef adv RIFAMPINA/uso terap Limits: HUMANO MASCULINO FEMININO CRIANÇA ADULTO ADOLESCENTE Electronic Medium: http://www.ilsl.br Location: BR191.1; 09123/s

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Id: 13444 Author: Tomecki, Kenneth J; Catalano, Charles J Title: Dapsone hypersensitivity ..- Source: s.l; s.n; jan. 1981. 2 p. . Abstract: A hypersensitivity reaction to low-dose (50-mg), short-term dapsone administration developed in a 16-year-old girl. The reaction included fever, malaise, dermatitis, jaundice with hepatic dysfunction, lymphadenopathy, and hemolytic anemia. Physicians should be familiar with this sulfone syndrome, an uncommon, potentially serious, side effect of dapsone therapy.(AU). Descriptors: ACNE VULGAR/quimioter ANEMIA HEMOLITICA/etiol DAPSONA/ef adv ERUPCAO POR DROGA/etiol HIPERSENSIBILIDADE A DROGAS/diag HEPATITE TOXICA/etiol DOENCAS LINFATICAS/ind quim SINDROME Limits: RELATO DE CASO HUMANO FEMININO ADOLESCENTE Electronic Medium: http://www.ilsl.br Location: BR191.1; 00741/s

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Id: 13263 Author: Tomecki, Kenneth J; Catalano, Charles J Title: Dapsone hypersensitivity ..- Source: s.l; s.n; jan. 1981. 2 p. . Abstract: A hypersensitivity reaction to low-dose (50-mg), short-term dapsone administration developed in a 16-year-old girl. The reaction included fever, malaise, dermatitis, jaundice with hepatic dysfunction, lymphadenopathy, and hemolytic anemia. Physicians should be familiar with this sulfone syndrome, an uncommon, potentially serious, side effect of dapsone therapy.(AU). Descriptors: ACNE VULGAR/quimioter ANEMIA HEMOLITICA/etiol DAPSONA/ef adv ERUPCAO POR DROGA/etiol HIPERSENSIBILIDADE A DROGAS/diag HEPATITE TOXICA/etiol DOENCAS LINFATICAS/ind quim SINDROME Limits: RELATO DE CASO HUMANO FEMININO ADOLESCENTE Electronic Medium: http://www.ilsl.br Location: BR191.1; 00724/s

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Id: 10971 Author: Pandey, V. P; Taneja, S; Talati, R Title: Acute renal failure and hepatitis induced by intermittent rifampicin therapy ..- Source: s.l; s.n; 1999. 1 p. . Descriptors: HANSENIASE TUBERCULOIDE LEPROSTATICOS LEPROSTATICOS HEPATITE TOXICA HEPATITE TOXICA INSUFICIENCIA RENAL AGUDA INSUFICIENCIA RENAL AGUDA RIFAMPINA RIFAMPINA Limits: RELATO DE CASO HUMANO MASCULINO ADULTO Location: BR191.1; 07461/s

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Id: 10021 Author: Dhamija, R; Kumar, D; Khurana, G Title: Dapsone syndrome ..- Source: s.l; s.n; 1995. 2 p. . Descriptors: DAPSONA DIAGNOSTICO DIFERENCIAL HIPERSENSIBILIDADE A DROGAS HIPERSENSIBILIDADE A DROGAS HIPERSENSIBILIDADE A DROGAS HEPATITE TOXICA LEPROSTATICOS HANSENIASE SINDROME Location: BR191.1; 06986/s

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Id: 9366 Author: Reeve, P. A; Ala, J; Hall, J. J Title: Dapsone syndrome in Vanuatu: a high incidence during multidrug treatment (MDT) of leprosy ..- Source: s.l; s.n; 1992. 5 p. tab. Descriptors: ADOLESCENCIA CLOFAZIMINA DAPSONA DAPSONA ERUPÇAO POR DROGA QUIMIOTERAPIA QUIMIOTERAPIA COMBINADA HEPATITE TOXICA INCIDENCIA HANSENIASE RIFAMPINA SINDROME VANUATU Location: BR191.1; 06433/s

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